The American Chamber of Commerce of the Philippines Inc. - Visayas Chapter is a private, independent and non-profit association incorporated under Philippines laws in July 1920. It is affiliated with the Chamber of Commerce of the U.S.A. (COCUSA) and the Asia-Pacific Council of American Chambers (APCAC).

It maintains close liaison with other foreign chambers in Manila and Philippine business groups: the Employers Confederation of the Philipppines (ECOP), Philippine Chamber of Commerce & Industry (PCCI), Philippine Association of Multinational Regional Headquarters (PAMURI), Makati Business Club (MBC), Management Association of the Philippines (MAP), Financial Executives Institute of the Philippines (FINEX), and other trade and business organizations.

It also networks in the U.S. with the Philippine-American Chamber of Commerce in New York, US-RP Business Committee, Asia Society, and the US-ASEAN Council.

AmCham works closely with the American Embassy in Manila, particularly with the Foreign Commercial Service, the Economic Section, the Agricultural Office, USAID, and the Consular Section.